MGMR™ is versatile intracellular delivery vehicle, consisting of a dispersion of hollow, nanoscale tubules approximately 1/10,000th the width of a human hair.
Eliminates viral-mediated transfection
- No risk of insertional mutagenesis
- No viral toxicity and immunogenicity
- Non-replicative
Delivers versatile loading profile effective for intracellular transport of:
- Gene-editing complexes
- Oligonucleotides
- Peptides/Proteins
Increases cell yield
Streamlines manufacturing and quality processes
- MGMR™ is extensively scalable with high physical consistency
- Non-biological transfection technology reduces variation
- Readily extractable from cell products
Reduces cell manufacturing and design costs
Lessens regulatory risks by providing non-viral transfection
- MGMR™ is removed from final cell product – MGMR™ doesn’t enter the body
Enables new capabilities
- MGMR™ is a scalable tool from manufacturing gene-edited cells
- Potential for serial, multiplex gene-editing
(Depicted to Scale)
The high aspect-ratio, nanoscale profile of MGMR™ allows it to readily penetrate cells without compromising membrane integrity or inducing cytotoxicity. Its high surface-to-volume ratio and tunable surface chemistry allow it to readily transport both small and large-molecular cargos into the cytoplasm, including oligonucleotides, peptides, proteins and genetic materials, vector and genetic materials.
Competitive Differentiation
