What is MGMR?

MGMR is versatile intracellular delivery vehicle, consisting of a dispersion of hollow, nanoscale tubules approximately 1/10,000th the width of a human hair.

 

How does MGMR™ improve cell manufacturing?

Eliminates viral-mediated transfection

  • No risk of insertional mutagenesis
  • No viral toxicity and immunogenicity
  • Non-replicative

Delivers versatile loading profile effective for intracellular transport of:

  • Gene-editing complexes
  • Oligonucleotides
  • Peptides/Proteins

Increases cell yield

Streamlines manufacturing and quality processes

  • MGMR™ is extensively scalable with high physical consistency
  • Non-biological transfection technology reduces variation
  • Readily extractable from cell products

Reduces cell manufacturing and design costs

Lessens regulatory risks by providing non-viral transfection

  • MGMR™ is removed from final cell product – MGMR™ doesn’t enter the body

Enables new capabilities

  • MGMR™ is a scalable tool from manufacturing gene-edited cells
  • Potential for serial, multiplex gene-editing

MGMR™ Next-generation Transfection Technology

(Depicted to Scale)

The high aspect-ratio, nanoscale profile of MGMR™ allows it to readily penetrate cells without compromising membrane integrity or inducing cytotoxicity. Its high surface-to-volume ratio and tunable surface chemistry allow it to readily transport both small and large-molecular cargos into the cytoplasm, including oligonucleotides, peptides, proteins and genetic materials, vector and genetic materials.

Competitive Differentiation